Skip to main content
. 2021 Oct 7;11:19915. doi: 10.1038/s41598-021-99064-8

Table 3.

Attempted asymmetric synthesis of decursivine using chiral BINOL phosphoric acid.

graphic file with name 41598_2021_99064_Figa_HTML.gif
Sr. No. Reaction conditions Yielda (%) eeb (%)
1 PIFA (1.2 equiv), (S)-BINOL phosphoric acid (0.05 equiv), HFIP, Ar, r.t., 3 h 74 –
2 PIFA (1.2 equiv), (R)-3,3'-bis(2,4,6-triisopropylphenyl)-BINOL phosphoric acid (0.05 equiv), HFIP, Ar, r.t., 3 h 67  < 2%

aIsolated yield after column chromatography.

bDetermined by HPLC.