Fig. 3. Experimental use-cases.

The task of cellular annotation is chosen, specifically owing to its highly repetitive nature, and the difficulty of complete data annotation (e.g., a section of tissue may contain 900,000 cells). Four use-cases highlight the generalizability of this method across stain types and cell types. From left to right: tumor-infiltrating lymphocytes (TILs), tumor cells, eosinophils, and Ki-67-stained cells of arbitrarily sufficient size, as determined by the annotators. Top row shows example cells of the specified type (positive), the bottom row shows examples of all others (negative). See Data Availability for image details.