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. 2021 Oct 7;12:5871. doi: 10.1038/s41467-021-26168-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a A schematic showing an implanted AAV-delivery probe in mouse brain. b Transduction characteristics of AAV9 vectors delivered through self-assembled probes. Images (left) are overlays of EYFP/mCherry fluorescence and bright field. Data (right) represent the mean ± SD (n = 4 mice in each group). Scale bar, 1 mm. c Spatially localized EYFP expression around implanted MEFs. The MEFs can be seen in the bright field image. d Neuronal expression of EYFP around MEFs. e Spatially localized mCherry expression of an implanted AAV9-hSyn::ChR2-mCherry-delivery probe at 3 weeks. Scale bars in (c-e), 100 and 50 μm (magnified views). f Spatially confined transgene expression of two closely implanted self-assembled probes in the same mouse brain. One probe was loaded with AAV9-hSyn::eNpHR3.0-EYFP (left), and the other was loaded with AAV9-hSyn::ChR2-mCherry (right). Scale bar, 200 μm.