TABLE 3.
Multivariate Analysis for Events in Nonobstructive CAD (1% to 49% Stenosis Left Main or 1% to 69% Stenosis Any Coronary Artery)
| HR (95% CI) | p Value | |
|---|---|---|
| Model 1: Traditional CV risk (n = 2,586) | ||
| Age (continuous) | 1.00 (0.97–1.04) | 0.813 |
| Male sex (vs. female sex) | 0.87 (0.55–1.38) | 0.561 |
| ASCVD risk (continuous) | 1.03 (1.01–1.05) | 0.007* |
| Model 2: CAD characteristics (n = 2,297) | ||
| ≥2 HRP (vs. <2 HRP) | 2. 24 (1.17–4.30) | 0.015* |
| CAC (continuous)† | 1.00 (1.00–1.00) | 0.101 |
| SIS (continuous) | 1.05 (0.95–1.15) | 0.343 |
| Mild/moderate stenosis (vs. minimal stenosis) | 1.87 (1.10–3.16) | 0.021* |
| Model 3: Traditional CV risk plus | ||
| CAD characteristics (using covariates with p < 0.20 from models 1 and 2) (n = 2,271)‡ | ||
| ASCVD risk (continuous) | 1.03 (1.01–1.04) | 0.001* |
| ≥2 HRP (vs. <2 HRP) | 2.40 (1.25–4.58) | 0.008* |
| Mild/moderate stenosis (vs. minimal stenosis) | 1.91 (1.16–3.16) | 0.011* |
| CAC (continuous)† | 1.00 (0.9999–1.0006) | 0.096 |
*
Significant (p < 0.05).
†
Similar results are found when using log CAC instead of CAC.
‡
Results are similar when using a full specified model that includes all variables (Supplemental Table 1).