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. Author manuscript; available in PMC: 2021 Oct 13.
Published in final edited form as: Mol Psychiatry. 2021 Apr 8;26(7):3043–3059. doi: 10.1038/s41380-021-01065-6

Figure 1. IFNAR antibody treatment attenuates chronic stress-induced deficits in social behavior and spatial working memory.

Figure 1.

(A-B) Chronic stress-induced changes in serum (A) IFNα and (B) IFNβ protein levels; *p =0.0348 vs NS; Student’s t test: n=9. (C-E) IFNAR antibody treatment attenuated chronic stress-induced deficits in social behavior and spatial working memory. C, Time in chamber in the three-chamber social interaction test. Two-way ANOVA, chamber (F(2,102)=53.75, p<0.0001); chamber X treatment interaction (F(6,102)=6.364, p<0.0001). **p<0.01 and ***p<0.001 (mouse chamber vs empty chamber); n=9–10 per group. D, Reciprocal social interaction test; Two-way ANOVA, stress (F(1,32)=7.617, p=0.0095); **p<0.01 vs Con Ab NS; n=9 per group. E, Y-maze test. Two-way ANOVA, stress (F(1,35)=6.898, p=0.0127); *p<0.05 vs Con Ab NS; n=9–10 per group. NS: no stress; RS: restraint stress.