TABLE 1.
Effects of antiarrhythmic drugs (AADs) on the electrophysiological and fibrillatory wave-dynamics parameters.
| Baseline (†n = 25) | Overall AADs (†n = 250) | P-value | Class IC AADs (†n = 100) | Class III AADs (†n = 150) | P-value | Low dose AADs (†n = 125) | High dose AADs (†n = 125) | P-value | |
| APD90 (ms) | 233.000 (231.000, 239.000) | 273.000 (263.000, 295.000) | <0.001 | 269.000 (256.000, 290.000) | 277.000 (265.000, 303.000) | 0.002 | 267.000 (261.000, 273.000) | 293.000 (271.000, 309.000) | <0.001 |
| CV (m/s) | 0.750 (0.617, 0.906) | 0.612 (0.411, 0.741) | 0.007 | 0.598 (0.474, 0.732) | 0.618 (0.395, 0.745) | 0.615 | 0.674 (0.484, 0.826) | 0.526 (0.346, 0.685) | <0.001 |
| Mean AFCL (ms) | 135.616 (130.526, 150.303) | 159.344 (145.632, 176.964) | <0.001 | 156.508 (140.000, 171.579) | 162.312 (150.923, 183.952) | 0.038 | 153.750 (140.000, 172.281) | 164.167 (156.508, 192.404) | <0.001 |
| Mean Smax | 0.785 (0.656, 0.963) | 0.802 (0.635, 1.009) | 0.899 | 0.851 (0.639, 1.027) | 0.744 (0.629, 0.998) | 0.136 | 0.730 (0.628, 0.916) | 0.851 (0.677, 1.106) | 0.003 |
| Mean DF (Hz) | 7.025 (6.097, 7.379) | 5.722 (1.286, 6.553) | <0.001 | 6.148 (5.315, 6.922) | 5.170 (1.200, 6.145) | <0.001 | 6.121 (5.082, 6.874) | 5.101 (1.200, 6.098) | <0.001 |
| COV-DF (%) | NA | 141.421 (105.265, 173.205) | NA | 149.079 (108.095, 173.205) | 141.421 (102.270, 170.349) | 0.001 | 141.000 (120.000, 141.000) | 141.000 (119.000, 141.000) | 0.918 |
APD90, Action potential duration 90%; CV, Conduction velocity; AFCL, AF cycle length; Smax, The Maximal slope of the restitution curves; DF, Dominant frequency; COV-DF, Coefficient of Variation-Dominant Frequency.
Patients who did not sustain proper normal sinus rhythm and an atrial fibrillation (AF) status were excluded from the analysis.
Median (IQ1, IQ3) was displayed in the Table.
†n = The number of patients × AAD × Dose.