TABLE 2.

Effects of antiarrhythmic drugs (AADs) on the pulmonary vein (PV) vs. Extra-PV tissue.

	Baseline			AAD
	PV (†n = 25)	Extra-PV (†n = 25)	P-value	PV (†n = 750)	Extra-PV (†n = 500)	P-value
Mean Smax	1.258 (1.060, 1.619)	1.418 (1.006, 1.729)	0.541	1.264 (0.802, 1.659)	1.290 (0.892, 1.663)	0.541
ΔMean Smax	NA	NA	NA	−0.027 (−0.219, 0.170)	0.006 (−0.326, 0.250)	0.692
Mean DF (Hz)	7.567 (6.246, 8.186)	7.916 (7.383, 8.595)	0.086	6.464 (5.246, 7.170)	7.029 (6.209, 7.659)	<0.001
ΔMean DF	NA	NA	NA	−0.820 (−1.275, −0.236)	−0.848 (−1.368, −0.298)	0.238
COV-DF (%)	NA	NA	NA	141.421 (117.963, 173.205) ‡140.446 ± 33.227	141.421 (97.825, 172.515) ‡130.932 ± 41.633	0.003

Smax, The Maximal slope of the restitution curves; ΔMean Smax, Changes of Smax; DF, Dominant Frequency; ΔMean DF, Changes of DF; COV-DF, Coefficient of Variation-Dominant Frequency.

Patients who did not sustain proper normal sinus rhythm and an atrial fibrillation (AF) status were excluded from the analysis.

Median (IQ1, IQ3) was displayed in the Table.

^†n = The number of patients × AAD × Dose.

^‡Mean ± SD.