TABLE 4.
Electrophysiological characteristics terminated atrial fibrillation (AF) after antiarrhythmic drugs (AADs).
| Defragmentation | Overall AADs | Class IC | Class III | ||||||
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| Defragmented ( † n = 290) | Not defragmented ( † n = 2210) | P-value | Defragmented ( † n = 60) | Not defragmented ( † n = 940) | P-value | Defragmented ( † n = 230) | Not defragmented ( † n = 1270) | P-value | |
| Mean Smax | 1.254 (1.022, 1.526) | 1.263 (0.923, 1.675) | 0.777 | 1.275 (0.920, 1.509) | 1.271 (0.901, 1.549) | 0.894 | 1.238 (1.036, 1.507) | 1.255 (0.941, 1.856) | 0.729 |
| Mean DF (Hz) | 5.476 (1.299, 6.706) | 6.913 (6.233, 7.466) | <0.001 | 5.770 (5.201, 6.563) | 7.118 (6.527, 7.860) | 0.029 | 5.262 (1.299, 6.640) | 6.710 (5.992, 7.227) | <0.001 |
| COV-DF (%) | 141.000 (139.000, 141.000) ‡126.166 ± 33.607 | 141.000 (108.500, 141.000) ‡117.571 ± 39.203 | <0.001 | 141.000 (140.750, 141.000) ‡136.285 ± 10.847 | 141.000 (109.750, 141.000) ‡117.432 ± 39.783 | <0.001 | 141.000 (138.250, 141.000) ‡123.734 ± 36.821 | 141.000 (98.625, 141.000) ‡115.311 ± 40.276 | 0.008 |
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| Termination | Overall AADs | Class IC | Class III | ||||||
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| Terminated ( † n = 230) | Not Terminated ( † n = 2270) | P-value | Terminated ( † n = 30) | Not Terminated ( † n = 970) | P-value | Terminated ( † n = 200) | Not Terminated ( † n = 1300) | P-value | |
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| Mean Smax | 1.265 (1.041, 1.437) | 1.263 (0.901, 1.675) | 0.704 | 0.812 (0.809, 1.059) | 1.264 (0.900, 1.552) | 0.281 | 1.294 (1.089, 1.481) | 1.255 (0.941, 1.856) | 0.885 |
| Mean DF (Hz) | 5.295 (1.299, 6.677) | 6.889 (6.170, 7.465) | <0.001 | 5.041 (3.170, 6.896) | 7.101 (6.469, 7.843) | 0.385 | 5.476 (1.299, 6.677) | 6.170 (5.507, 6.684) | 0.084 |
| COV-DF (%) | 141.000 (139.500, 141.000) ‡126.312 ± 33.185 | 141.000 (103.000, 141.000) ‡116.545 ± 40.083 | <0.001 | 141.000 (136.000, 141.000) ‡131.124 ± 19.179 | 141.000 (113.000, 141.000) ‡118.718 ± 38.890 | 0.199 | 141.000 (141.000, 141.000) | 138.000 (85.750, 141.000) | <0.001 |
Smax, The Maximal slope of the restitution curves; DF, Dominant Frequency; COV-DF, Coefficient of Variation-Dominant Frequency.
Defragmentation: Termination + Atrial Tachycardia.
Patients who did not sustain proper normal sinus rhythm and an AF status were excluded from the analysis.
Median (IQ1, IQ3) was displayed in the Table.
†n = The number of patients × AAD × Dose.
‡Mean ± SD.