Table 1.

Summarizes the role of various TJ in cancer.

Type of cancer	Downregulation	References	Upregulation	References
Colorectal carcinoma	Claudin 4,7 ZO- 1 Claudin 8	Suren et al., 2014 Kaihara et al., 2003 Grone et al., 2007	Claudin 2 Claudin 1 Occludins Claudin 12	Buhrmann et al., 2015 Sun et al., 2015 Grone et al., 2007
Gastric cancer	Claudin 17	Gao et al., 2013	Claudin 1 Claudin 4	Huang et al., 2014 Hwang et al., 2014
Hepatocellular carcinoma	Claudin 11 Claudin 14	Németh et al., 2008 Akizuki et al., 2017	Claudin 1 ZO-1 Claudin 11	Suh et al., 2013 Ram et al., 2018
Breast cancer	Claudin 1 ZO 1 ZO 2	Kim et al., 2008 Morohashi et al., 2007 Hoover et al., 1998 Chlenski et al., 2000	Claudin 3 Claudin 4 Claudins 20	Jaaskelainen et al., 2018 Jiwa et al., 2014 Martin et al., 2013
Lung cancer	Claudin 18 Claudin 7	Akizuki et al., 2017 Kudinov et al., 2016	Claudin 10	Zhang et al., 2013
Pancreatic cancer	ZO 2 ZO 1	Chlenski et al., 1999 Hoover et al., 1998	Claudin 4	Long et al., 2001
Renal cancer			Claudin 16	Buhrmann et al., 2015