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. 2021 Sep 24;12:721775. doi: 10.3389/fphys.2021.721775

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Copyright © 2021 Xu, Xie, Zhao, Wu, Wang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular analyses of mandibles from Gli1^Lin Tgfβr2 conditional knockout (cKO) mice (A) The confocal images revealed a great reduction in bone volume and number of Gli1^lin Ocy in cKO alveolar bone, which is statistically significant from the control (right panel); (B) The OSX immunostaining images showed a significant decrease in the raito of OSX⁺-Gli1^Lin Ocy to the total Gli1^lin Ocy; (C) The confocal images of MEPE immunostainings showed a significant reduction in the raito of MEPE⁺-Gli1^Lin Ocy to the total Gli1^lin Ocy in the cKO alveolar bone (right panel); (D) The confocal images of SOST immunostainings showed an increase in the raito of SOST⁺-Gli1^Lin Ocy to the total Gli1^Lin Ocy in the cKO alveolar bone, which was statistically significant from the control (right panel). n =4. *P < 0.05; Ocy, osteocytes.