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. 2021 Sep 24;12:721775. doi: 10.3389/fphys.2021.721775

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Copyright © 2021 Xu, Xie, Zhao, Wu, Wang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary: TGFβ signaling plays a stage-dependent role during mandible bone growth based on the loss of Tgfβr2 in Gli1+ osteogenic progenitors and 3.2 kb Col1+ osteoblasts in the R26R^tdTomato tracing background, respectively. Removing Tgfβr2 in the Gli1+ progenitor cells at early postnatal stage led to a significant bone loss and a decrease in OSX. Deletion of Tgfβr2 in the 3.2 kb Col1+ osteoblasts at early postnatal stage result in mild changes in alveolar bone morphologies and bone volume.