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The GPX mediated reduction of hydrogen peroxide and lipid hydroperoxides involves the formation of multiple intermediates with the assistance of glutathione (GSH). The selenol (–SeH) of GPX reacts with peroxides to form selenic acid (Se-OH). Then the selenic acid is reduced by GSH to form the Se-SG intermediate of GPX. GPX-Se-SG was reduced by the second GSH to form GSSG. GSSG can be reduced by glutathione reductase (GR) as reduced equivalent by NADPH.
