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. 2021 Sep 24;12:716684. doi: 10.3389/fphar.2021.716684

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Copyright © 2021 Yang, Ma, Zhang, Sun, Zhang, Chang, Lin and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The anti-inflammatory function of Hig was evaluated by its effect on the expression of inflammatory factors. (A, B) The RSC96 intercellular mRNA expression levels of TNF-α and IL-6 were measured by RT-qPCR. (C–E) The expression levels of TNF-α, IL-6, and IL-1β in rats serum were detected by specific ELISA kits. The results are presented as mean ± SEM, n = 6. ###p < 0.001 and ####p < 0.0001 vs. the control group. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 vs. the model group.