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. 2021 Sep 24;12:716684. doi: 10.3389/fphar.2021.716684

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Copyright © 2021 Yang, Ma, Zhang, Sun, Zhang, Chang, Lin and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hig relieved mechanical allodynia and heat hyperalgesia in CCI rats by raising the thresholds of MWT and TWI. (A) The value of MWT in each group was detected by the von Frey test on the day before the surgery and days 3, 5, 7, 10, 14, and 21 after surgery. (B) The value of TWI in each group was detected by the hot-plate test. The results are presented as mean ± SEM, n = 8. ####p < 0.0001 vs. the control group. *p < 0.05, ***p < 0.001, and ****p < 0.0001 vs. the CCI group.