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Hig protected DRG neuron against CCI-induced oxidative stress and apoptosis by regulating mitochondrial pathway. WB analysis was used to quantify the ratio of Bcl-2/Bax and cleaved caspase 3/caspase 3 protein level and the expression level of cyt-c protein. GAPDH was considered as an internal control. The results are presented as mean ± SEM, n = 3. ###p < 0.001 and ####p < 0.0001 vs. the control group. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 vs. the t-BHP group.
