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. 2021 Sep 24;8:736485. doi: 10.3389/fmed.2021.736485

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Copyright © 2021 van Batenburg, van Oosterhout, Knoppert, Kazemier, van der Vis, Grutters, Goldschmeding and van Moorsel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative Hematoxylin and Eosin (H&E)-stained diagnostic biopsies of FPF/IPF and cNSIP lungs. Images of typical (A) FPF/IPF and (C) cNSIP lung biopsies. (B,D) Magnifications of boxed areas in images (A,C), respectively. Fibroblast foci (asterisk) and lymphocyte aggregates (arrow) were digitally quantified in the whole biopsy and the amount of diffuse inflammatory cell infiltrate (blue-purple nuclei) of the whole biopsy was scored using a histological grade from 1 to 4. Horizontal bars represent a size of 200 μm. FPF, Familial pulmonary fibrosis; IPF, idiopathic pulmonary fibrosis; cNSIP, cellular non-specific interstitial pneumonia; NF, non-fibrotic area; F, fibrotic area.