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. 2021 Sep 24;12:759267. doi: 10.3389/fphar.2021.759267

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Copyright © 2021 Zhang, Wang, Ke, Liu, Guo, Fang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of LINC01001 depresses crizotinib-resistance of NSCLC cells. (A) RT-qPCR detected the levels of LINC01001. (B) CCK-8 assay evaluated the viability of crizotinib-resistant NSCLC cells. (C) EdU assay assessed the proliferation of crizotinib-resistant NSCLC cells. (D) Western blot measured the levels of proliferation-related proteins, including PCNA and Ki-67. (E) FACs assessed apoptosis of crizotinib-resistance NSCLC cells. (F) TUNEL staining performed to evaluate apoptosis of crizotinib-resistant NSCLC. **p < 0.01, ***p < 0.001 vs sh-NC group. Error bars represent SD. Data represent three independent experiments.