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. 2021 Sep 24;12:759267. doi: 10.3389/fphar.2021.759267

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Copyright © 2021 Zhang, Wang, Ke, Liu, Guo, Fang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LINC01001 interacts with IGF2BP2. (A) Subcellular fractionation evaluated the localization of LINC01001 in crizotinib-resistant NSCLC cells. **p < 0.01, ***p < 0.001 vs Cytoplasm (B) Bioinformatics analysis indicated LINC01001 interacted with IGF2BP2. (C) RIP assay evaluated the interaction between LINC01001 and IGF2BP2 in drug resistant cells. ***p < 0.001 vs IgG group (D) RNA pulldown assay confirmed the interaction between LINC01001 and IGF2BP2. ***p < 0.001 vs Bio-NC group (E) RT-qPCR was conducted to assess the level of IGF2BP2 in crizotinib-resistance NSCLC cells. ***p < 0.001 vs WT group. Error bars represent SD. Data represent three independent experiments.