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. 2021 Sep 24;12:759267. doi: 10.3389/fphar.2021.759267

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Copyright © 2021 Zhang, Wang, Ke, Liu, Guo, Fang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LINC01001 overexpression increases crizotinib-resistance of NSCLC cells via MYC. (A) RT-qPCR and western blot detected the level of MYC. (B) CCK-8 assay assessed the viability of crizotinib-resistant NSCLC cells. (C) EdU assay evaluated the proliferation of crizotinib-resistant NSCLC cells. (D) Western blot examined the level of proliferation-related proteins. E, FACs detected apoptosis of crizotinib-resistant NSCLC cells. F, TUNEL assessed apoptosis of crizotinib-resistant NSCLC cells. **p < 0.01, ***p < 0.001 vs NC group, #p < 0.05, ##p < 0.01, ###p < 0.001 vs LINC01001+sh-NC group. Error bars represent SD. Data represent three independent experiments.