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. 2021 Sep 24;12:732573. doi: 10.3389/fphys.2021.732573

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Copyright © 2021 Lyon, van Opbergen, Delmar, Heijman and van Veen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Calcium-handling properties [L-type calcium current (I_Ca,L), calsequestrin protein levels, calcium transient and diastolic calcium concentrations] measured experimentally (modified from Cerrone et al., 2017) (^**p < 0.01) in wildtype (WT) (black) and PKP2-cKO (red) cardiomyocytes (left), and corresponding simulated data [I_Ca,L, free sarcoplasmic reticulum (SR) calcium concentration, calcium transient] (right).