Figure 6.

(A) Scaling multiplier of RyR2 and I_NCX between models that still show DADs after a reduction in RyR2 calcium affinity (RyR2-insensitive, blue) and the ones who do not show DADs after reduction (RyR2-sensitive, red). (B) Percentage of models showing DADs when comparing; the PKP2-cKO model with no Cx43 hemichannel-mediated calcium influx, PKP2-cKO model plus BARS (1.5-fold Cx43 hemichannel-mediated calcium influx incorporated), with or without reduced RyR2 affinity, the PKP2-cKO model plus BARS (1.5-fold Cx43 hemichannel-mediated calcium influx), with or without reduced RyR2 activity, doubled I_NCX in the RyR2-insensitive group or a 50% reduction of I_NCX in the RyR2-sensitive group (top); the corresponding calcium traces (bottom).