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. 2021 Sep 24;12:732573. doi: 10.3389/fphys.2021.732573

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Copyright © 2021 Lyon, van Opbergen, Delmar, Heijman and van Veen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Diastolic cleft calcium levels upon a reduced RyR2 calcium affinity (blue) and on top of that an increased I_NCX (red). (B) Percentage of models showing DADs, plotted against the diastolic cleft calcium levels presented for six different situations in the PKP2-cKO model (top); Corresponding calcium traces (bottom).