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(A) Calcium transients in the human WT, PKP2-cKO and PKP2-cKO model, with various increments of Cx43 hemichannels-mediated calcium entry, applied in the Grandi human ventricular cardiomyocyte model. (B) Calcium transients in the PKP2-cKO model with no Cx43 calcium influx with and without BARS, and PKP2-cKO model plus BARS, RyR2 calcium affinity reduction and increased INCX.
