Table 1.
Summary table of the parameters changed in the original model (Morotti et al., 2014) to simulate the PKP2-cKO experimental characteristics, their interpretation, their values in the original WT and PKP2-cKO model and the relative change between WT and PKP2-cKO.
| Model parameter | Interpretation | WT value | PKP2-cKO value | Relative change |
|---|---|---|---|---|
| Vjunc | Junctional volume | 1.78e-14 L | 1.07e-14 L | ×60% |
| Bmax_Csqn | Calsequestrin buffer concentration | 2.7 mM | 1.22 mM | ×45.3% |
| ICa_scale | Scaling of ICa, L | 1 | 0.5 | ×50% |
| r2m2 | L-type calcium channel (LTCC) closing rate | 0.38 ms−1 | 0.28 ms−1 | ×75% |
| ks | SR Ca release rate | 25 ms−1 | 15 ms−1 | ×60% |
| kleak | SR Ca passive leak rate | 1.22.10−05 ms−1 | 7.32. 10−06 ms−1 | ×60% |