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. 2021 Sep 24;14:726331. doi: 10.3389/fnmol.2021.726331

FIGURE 5.

FIGURE 5

Contributions of oxidative phosphorylation and glycolysis to steady state NGF (24 h treatment) driven pT308-Akt and pS473-Akt phosphorylation. (A) Effects of a 30 and 60 min treatment with antimycin-A on the density of pT308-Akt puncta in axons. A 30 min treatment decreased the density that, however, restored to the time matched control levels by 60 min. (B) A 10 min treatment with AA decreased the density of pT308-Akt punctato a similar extent as a 30 min treatment (A), and below those present in no NGF conditions. (C) GIM treatment for 30 and 60 min similarly decreased the density of pT308-Aktpuncta. (D) The restoration of the density of pT308-Akt punctato baseline after a 60 min treatment with AA is prevented by cotreatment with GIM. (E) Treatment with AA decreases the density of pS473-Akt puncta after a 60 min treatment but not a 30 min treatment. (F) Both 30 and 60 min treatments with GIM similarly decrease the density of pS473-Akt puncta.