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. 2021 Sep 24;9:666303. doi: 10.3389/fcell.2021.666303

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Copyright © 2021 Tan, Zhang, Li, Zhan, Qiao, Wu, Sun, Huang, Zhang, Zhang, Li, Li and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model depicting the molecular mechanisms of LGR4 mediated WNT signaling that activates the transcription factor NR5A2 to bind on the promoters of the steroidogenic genes, Cyp11a1 and Hsd3b1.