Table 1.

Currently available insulins and their action time

Type of insulin		Onset time	Peak time	Duration of action
Ultrarapid-acting
	Insulin aspart (Fiasp®)	4 min	1–3 hr	3–5 hr
	Insulin lispro-aabc (Lyumjev®)	2 min	1–2 hr	~4.6 hr
Rapid-acting
	Insulin lispro (Humalog®)	10–15 min	1–2 hr	3–5 hr
	Insulin aspart (NovoRapid®)	10–15 min	1–3 hr	3–5 hr
	Insulin glulisine (Apidra®)	10–15min	1–2 hr	2–4 hr
Short-acting
	Regular insulin (Humulin R®)	30 min	2–3 hr	6.5 hr
Intermediate-acting
	NPH insulin (Humulin N®)	1–3 hr	5–8 hr	~18 hr
Long-acting
	Insulin glargine (Lantus®)	1.5 hr	No peak	~24 hr
	Insulin glargine U300 (Toujeo®)	~6 hr	No peak	24–36 hr
	Insulin detemir (Levemir®)	3–4 hr	6–8 hr	~24 hr
	Insulin degludec (Tresiba®)	30–90 min	No peak	~42 hr
Premixed
	70% NPH+30% regular insulin (Humulin® 70/30)
	25% lispro+75% neutral protamine lispro (Humalog® Mix25)
	50% lispro+50% neutral protamine lispro (Humalog® Mix50)
	30% aspart+70% neutral protamine aspart (Novomix® 30)
	50% aspart+50% neutral protamine aspart (Novomix® 50)
	70% degludec+30% aspart (Ryzodeg®)

NPH, Neutral Protamine Hagedorn.