Table 2.
PDCD1LG2 SNPs associated with lung adenocarcinoma risk.
| SNP | Allele a | MAF | β | OR (95% CI) | p b | Annotation |
|---|---|---|---|---|---|---|
| rs2381282# | T/C | 0.357 | 0.149 | 1.160 (1.001, 1.345) | 0.049 | intron_variant |
| rs4742103# | C/T | 0.304 | -0.221 | 0.802 (0.676, 0.950) | 0.011 | intron_variant |
| rs4237162 | C/T | 0.221 | 0.235 | 1.264 (1.058, 1.511) | 0.010 | intron_variant |
| rs4742104# | C/T | 0.425 | -0.185 | 0.831 (0.715, 0.966) | 0.016 | intron_variant |
| rs12237624# | C/T | 0.043 | 0.390 | 1.476 (1.033, 2.111) | 0.033 | intron_variant |
| rs78096119# | A/G | 0.047 | 0.365 | 1.440 (1.027, 2.020) | 0.035 | intron_variant |
| rs6476988# | A/G | 0.273 | 0.166 | 1.181 (1.003, 1.390) | 0.046 | intron_variant |
| rs7857315# | T/C | 0.273 | 0.176 | 1.192 (1.013, 1.404) | 0.035 | intron_variant |
| rs10975178# | A/G | 0.294 | 0.178 | 1.195 (1.019, 1.402) | 0.028 | intron_variant |
| rs7854413 | C/T | 0.101 | -0.294 | 0.745 (0.588, 0.945) | 0.015 | missense_variant I (ATA) –> T (ACA) synonymous_variant D (GAT) –> D (GAC) |
| rs56001683# | G/T | 0.109 | -0.240 | 0.786 (0.627, 0.987) | 0.038 | intron_variant |
| rs7858319# | C/A | 0.108 | -0.241 | 0.786 (0.625, 0.988) | 0.039 | intron_variant |
CI, confidence interval; MAF, minor allele frequencies; OR, odds ratio; SNP, single nucleotide polymorphism; UTR, untranslated region.
a
Minor/major allele.
b
Covariates of age, education levels, body mass index, first-degree family with a history of lung cancer, history of pulmonary tuberculosis infection, cooking time in years, cooking with fume extractor, and environmental tobacco smoking exposure were used as adjusted variables.
#Imputed SNP.