Table 3.
Correlation between PDCD1LG2 SNPs and pulmonary TB for lung adenocarcinoma susceptibility.
| SNP | Genotype/TB | Case | Control | Odds Ratio | Adjusted p-value a | p-value for correlation b |
|---|---|---|---|---|---|---|
| rs12237624 | TT + no TB | 987 (86.88%) | 930 (91.45%) | 1 | 0.040 | |
| CT/CC + no TB | 99 (8.71%) | 70 (6.88%) | 1.975 (0.392 - 9.938) | 0.409 | ||
| TT + TB | 46 (4.05%) | 13 (1.28%) | 3.605 (1.688 - 7.699) | < 0.001 | ||
| CT/CC + TB | 4 (0.35%) | 4 (0.39%) | NA | NA | ||
| rs78096119 | GG + no TB | 978 (86.09%) | 925 (90.95%) | 1 | 0.031 | |
| AG/AA + no TB | 109 (9.60%) | 75 (7.37%) | 1.957 (0.392 - 9.772) | 0.413 | ||
| GG + TB | 46 (4.05%) | 11 (1.08%) | 4.075 (1.842 - 9.014) | < 0.001 | ||
| AG/AA + TB | 4 (0.35%) | 5 (0.49%) | NA | NA |
NA, data not available; SNP, single nucleotide polymorphism; TB, tuberculosis.
a
Adjusted for education level, cooking time, and passive smoking.
b
The p-values were obtained from the additive model ( Supplementary Table S2 ). Covariates of age, education levels, body mass index, first-degree family with a history of lung cancer, history of pulmonary tuberculosis infection, cooking time in years, cooking with fume extractor, and environmental tobacco smoking exposure were used as adjusted variables.