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. 2021 Sep 24;11:743556. doi: 10.3389/fonc.2021.743556

Table 1.

Signal transmission between drug-resistant cells and sensitive cells.

Disease Cells Drug resistance Exosomal RNA Mechanism/pathway References
Lung cancer Cisplatin miR-100-5p mTOR (43)
Hepatocellular carcinoma Bel/5-FU Bel7402 Multidrug resistance miR-32-5p PTEN/PI3K/Akt (44)
Breast cancer MCF-7 Adriamycin miR-222 (45)
Colon cancer RKO
Caco-2
Cetuximab PTEN/Akt (46)
non-small cell lung cancer A549-GR Gemcitabine miR-222-3p SOCS3 (47)
Hepatocellular carcinoma HepG2
PLC-PRF5
Sorafenib linc-RoR TGFβ (48)
Renal Cancer Sunitinib lncARSR miR-34/miR-449
AXL/c-MET
(49)