Figure 3.

Treatment gradually shifts microbiomes of children with AD towards healthy-like microbiota. (A) The relative abundance of S. aureus decreases significantly (p=1.4x10^-5) with treatment from visit 1 (31.83%) to visit 4 (1.90%) across likely lesional sites on AD patients. The decrease in relative abundance of S. aureus is significant across treatment groups (+DBB, p<0.001, -DBB, p=0.014, Supplementary Figure 1 ). (B) By visit 4 (cyan), the composition of microbiota of likely lesional sites on AD patients is much more similar to healthy controls (dark grey) than at visit 1 (yellow), although there is variation in the severity of disease at both timepoints (PCoA on Bray-Curtis distance). (C) Severity of disease as measured by SCORAD decreases with treatment across visits.