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. 2021 Sep 24;12:716380. doi: 10.3389/fphar.2021.716380

FIGURE 2.

FIGURE 2

Panel (A)-SVT-LCN release in simulated nasal electrolyte solution (SNES) pH 6.5 (green dots) and with the addition of lysozyme 0.5 mg/ml (pink diamonds) and lysozyme 0.5 mg/ml + phospholipase A2 (PLA2) 0.6 µg/ml (blue triangles). Panel (B)-SVT-LCN release in SNES (green dots), simulated nasal mucus (SNES plus porcine stomach mucin type II at 1% w/v, pH 6.5; red squares) and with the addition of lysozyme 0.5 mg/ml + phospholipase A2 (PLA2) 0.6 µg/ml (blue triangles). Experiments (n = 3, ± S.D.) were carried out in a vertical Franz cell apparatus using a cellulose dialysis membrane over a 24-h period.