FIGURE 5.

Dose–response evaluation of the treatment with SVT solution and SVT-LCNs on the secretion of IL-6 (A) and TNF-a (B) from THP-1 glia-like cells after LPS treatment (0.25 µg/ml) following protocol B as shown in Figure 4. Basal cytokine levels, LPS stimulus alone, and blank LCNs (the nanoparticle amount corresponding to 10 µM of SVT) are presented as controls. Data are expressed as mean percentage ± S.D. of cytokine secretion from at least three repeated measurements. Statistical significance of the results is expressed in comparison to that of the LPS treatment (*p < 0.05; ***p < 0.001; p****<0.0001) or to 10 µM SVT solution (§ p < 0.05; §§ p < 0.01, T).