Figure 1.

IL-15 KO + RIC alloSCT recipients develop hyperacute GVHD. C57BL/6 WT mice were irradiated with MAC, and IL-15 KO mice were irradiated with RIC, followed by alloSCT. Mice were monitored daily for (A) body weight and (B) clinical scores, and (C) donor cell engraftment and (D) plasma cytokine concentrations of IL-6 and IFNγ on days 3 and 6. (E) Mice were killed on day 6 post-alloSCT, and GVHD histology was conducted on gut tissue. Statistical analysis was performed using Mann-Whitney unpaired T test. *p < 0.05, **p < 0.01.