TABLE 1.

The dual roles of ISR in various cancers.

Role of ISR in cancers	Cancer type
Mediator of ISR is up-regulated in anoxic tumor cells	Breast cancer Ishizawa et al. (2016)
Mediator of ISR is up-regulated in hypoxic tumor cells	Cervical cancer Hartleben et al. (2021)
Adaptation to hypoxia	Glioblastoma and colorectal cancer Darini et al. (2019)
Promotes survival of therapy-resistant hypoxic tumor cells	Glioblastoma Darini et al. (2019)
Contribute to the resistance to anoikis and promote metastasis	Fibrosarcoma Obeng et al. (2006)
ER stress is transmitted from tumor cells to myeloid cells and then facilitate tumor progression	Prostate cancer Obiedat et al. (2020)
Increase or decrease the incidence of tumor	Medulloblastoma Kato et al. (2018)
Contributes to chemoresistance	BRAF mutated melanoma Long et al. (2013)
Contributes drug sensitivity to Trastuzumab	HER2+ breast cancer Lamora et al. (2015)