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. 2021 Sep 24;15:724307. doi: 10.3389/fnins.2021.724307

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Copyright © 2021 Gagné, Deshaies, Sidibé, Benchaar, Arbour, Dubinski, Litt, Peyrard, Robitaille, Sephton and Vande Velde.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of hnRNP A1B in the spinal cord throughout development and aging. (A) Immunoblot of mouse spinal cord at different ages, when possible the lumbar region was micro-dissected before lysis, blots are representative of n = 3. (B) Quantification of the mean intensity of hnRNP A1B (top left), dimeric hnRNP A1B (top right) and hnRNPA1 (bottom left) normalized to Ponceau, n = 3, two-way ANOVA (time variation: hnRNP A1B p = 0.1616, hnRNP A1B dimer p < 0.0001, hnRNP A1B dimer p < 0.0001). (C) qPCR of hnRNP A1B and hnRNP A1/A1B total mRNA levels expressed relative to the average of housekeeping control genes, n = 3, 2-way ANOVA (time variation: hnRNP A1B p = 0.0039).