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. 2021 Sep 24;9:761302. doi: 10.3389/fbioe.2021.761302

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Copyright © 2021 Dong, Zhu, Zhang, Wang, Wang, Huang, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BMMSC and EPCs dual-loaded CMC/ALG scaffolds for enhanced bone regeneration in ONFH (Xu et al., 2021). (A) Morphology of the scaffold for in vivo transplantation. The SEM micrograph showed the porous structure of the scaffold. And CCK-8 assay results confirmed that CMC/ALG scaffolds generated no cytotoxicity effects on BMSC/EPC viability. (B) Representative MRI photograph of the normal rabbit and the rabbit model. 2D and 3D micro-CT images of the femoral head in normal group and model group. (C) H&E staining of the empty lacuna in the necrotic region of the femoral head for each group. Reproduced with permission (Xu et al., 2021). Copyright 2021, Wiley Periodicals LLC.