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. 2021 Sep 24;9:761302. doi: 10.3389/fbioe.2021.761302

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Copyright © 2021 Dong, Zhu, Zhang, Wang, Wang, Huang, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polymer scaffold carrying VEGF is beneficial to vascular regeneration during osteonecrosis. (A) Schematic illustration for preparation of injectable hydrogel composite with VEGF loaded microspheres and vascular endothelial cells. Representative histological evaluation of cross sections retrieved at week 2, 4 and 6 after implantation of hydrogels composited with VEGF loaded microspheres. VEGF refers to vascular endothelial growth factor, VECs refers to vascular endothelial cells, (B) refers to blood cells, BV refers to blood vessels. The black arrow refers to the position of (B) or BV in the figures. Reproduced with permission (Chen et al., 2018). Copyright 2018, Elsevier Ltd.