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. 2021 Sep 24;12:727000. doi: 10.3389/fphys.2021.727000

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Copyright © 2021 Sun, Pan, Karey, Chen, Pinkerton, Wilson and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of apamin on spiking responses to step current injections. (A) Spiking responses to step current injections before (aCSF) and during apamin perfusion. Apamin had a smaller effect in the SHS group at a given injected current (A1), total number of spikes (A2), and membrane voltage (A3). (B) mAHP amplitude before and during apamin perfusion. Apamin had a smaller effect in the SHS group at same injected current (B1) and membrane voltage (B3) but not at same total discharge rate (B2). (C) mAHP area before and during apamin perfusion. As in the case of mAHP amplitude, apamin had a smaller effect in the SHS group at same injected current (C1) and membrane voltage (C3) but not at same total discharge rate (C2). (D) Three-way repeated measures ANOVA results. *p < 0.05 SHS vs. FA, ^†p < 0.05 apamin vs. aCSF, ^§p < 0.05 exposure x apamin interaction.