TABLE 1.
Baseline subject characteristics
| Characteristics | n = 11,440 |
|---|---|
| Age, years (SD) (range) | 50.3 (12.5) (18–79) |
| Sex, M:F (%) | 4792:6648 (41.9:58.1) |
| BMI, kg/m2 (SD) (range) | 26.7 (4.8) (16–57) |
| Obese (BMI > 30 kg/m2), n (%) | 2075 (21.8) |
| Diabetes mellitus, n (%) | 1540 (13.5) |
| High blood pressure, n (%) | 5206 (53.6%) |
| Waist circumference, cm (SD) (range) | 90.4 (13.5) (55–178) |
| Systolic blood pressure, mm Hg (SD) (range) | 130.2 (16.8) (130–17) |
| Diastolic blood pressure, mm Hg (SD) (range) | 77.8 (9.8) (40–127) |
| TE, kPa (SD) | 5.2 (4.1) |
| TE, KPa (median) (range) | 4.5 (2–72) |
| ALT, IU/L (SD) (range) | 24.4 (17.4) (1–459) |
| AST, IU/L (SD) (range) | 24.4 (12.7) (2–402) |
| GGT, IU/L (SD) (range) | 31.7 (51.2) (19–2045) |
| Alkaline phosphatase, IU/L (SD) (range) | 71.9 (28.7) (2–790) |
| Bilirubin, mg/dl (SD) (range) | 1.4 (17.6) (0.03–8) |
| Abnormal transaminases (AST or ALT > 40 IU/L), n (%) | 1113 (9.7) |
| Abnormal healthy transaminase levels, n (%) | 4061 (35.5) |
| Platelets, x103/ml (SD) (range) | 246.5 (62.0) (21–725) |
| Albumin, g/dl (SD) (range) | 4.5 (0.3) (2.7–5.6) |
| HDL cholesterol, mg/dl (SD) (range) | 58.8 (16.1) (8–116) |
| Triglycerides, mg/dl (SD) (range) | 141.2 (98.4) (20–400) |
| Glucose, mg/dl (SD) (range) | 91.6 (29.1) (42–344) |
| Metabolic syndrome ç(NCEP‐ATP‐III), n (%) | 1765 (15.4) |
| Harmful use of alcohol, n (%) | 1049 (9.2) |
| Anti‐HCV Ab+, n (%) | 143 (1.3) |
| HBsAg+, n (%) | 90 (0.8) |
| FIB‐4 (SD) | 1.1 (0.7) |
| FIB‐4 ≥ 3.24, n (%) | 106 (0.9) |
| APRI (SD) | 0.3 (0.2) |
| APRI ≥ 1, n (%) | 79 (0.7) |
Note: Quantitative data are expressed as mean (standard deviation). Qualitative data are expressed as number and percentage. Healthy transaminase levels were defined as ALT > 30 IU/L for men and ALT > 19 IU/L for women.
Abbreviations: Anti‐HCV Ab+, positive for anti‐hepatitis C virus antibodies; APRI, ALT to Platelet Ratio Index; FIB‐4, Fibrosis‐4 score; HBsAg+, positive for hepatitis B surface antigen.