TABLE 2.
Univariate and multivariate analysis
| Significant fibrosis (n = 641) | Absence of fibrosis (10,799) | p | Multivariate analysis | |
|---|---|---|---|---|
| Age (y) | 55.0 (10.9) | 50.1 (12.0) | <0.001 | OR 1.03 (1.02–1.04; p < 0.001) |
| Gender (M:F) | 347:294 (54.1:45.9) | 4445:6354 (41.2:58.8) | <0.001 | OR 0.8 (0.6–0.95; p = 0.02) |
| BMI (kg/m2) | 29.4 (6.1) | 26.6 (4.7) | <0.001 | |
| Waist circumference (cm) | 99.4 (16.3) | 90.0 (13.2) | <0.001 | |
| Systolic/diastolic blood pressure (mmHg) | 136.1 (17.6)/79.2 (10.2) | 129.9 (16.7)/77.7(9.8) | <0.001 | |
| Liver test | ||||
| ALT (IU/L) | 34.7 (30.3) | 23.8 (16.1) | <0.001 | OR 1.01 (1.01–1.02; p < 0.001)OR 1.005 (1.003–1.006; p < 0.001) |
| AST (IU/L) | 32.2 (22.6) | 24.0 (11.7) | <0.001 | |
| GGT (IU/L) | 63.4 (95.8) | 29.7 (46.6) | <0.001 | |
| Alkaline phosphatase (IU/L) | 79.2 (36.6) | 71.5 (28.1) | <0.001 | |
| Bilirubin (mg/dl) | 1.2 (15.1) | 1.4 (17.7) | 0.8 | |
| Abnormal transaminases (AST or ALT > 40 IU/L) | 172 (26.8) | 941 (8.7) | <0.001 | |
| Healthy transaminase cutoffs (ALT <30 male or <19 female) | 416 (64.9) | 5550 (51.4) | <0.001 | |
| Albumin (g/dl) | 4.5 (0.3) | 4.5 (0.3) | 0.5 | |
| Glucose (mg/dl) | 102.0 (47.6) | 91.0 (27.5) | <0.001 | |
| Platelets (x103) | 237.0 (77.6) | 247.1 (61.0) | <0.001 | |
| HDL cholesterol (mg/dl) | 54.6 (16.3) | 59.1 (16.1) | <0.001 | |
| Triglycerides (mg/dl) | 168.3 (108.5) | 139.6 (97.5) | <0.001 | |
| Metabolic syndrome (NCEP ATP III) | 171 (38.2) | 1594 (18.7) | <0.001 | OR 2.1 (1.7–2.6; p < 0.001) |
| HCV Ab+ | 12 (1.9) | 131 (1.2) | 0.1 | |
| HBsAg+ | 11 (1.7) | 79 (0.7) | 0.01 | |
| Harmful use of alcohol | 85 (13.3) | 964 (8.9) | <0.001 | |
Note: Significant fibrosis (LSM > 8 kPa) versus absence of fibrosis. Quantitative data are expressed as mean (standard deviation). Qualitative data are expressed as number and percentage. Variables included in the multivariate analysis: age, gender, ALT, AST, GGT, alkaline phosphatase, platelets, metabolic syndrome, HBsAg+, alcohol consumption.