TABLE 4.
Univariate and multivariate analysis
| Highly suggestive cACLD (n = 141) | Absence of cACLD (n = 11299) | p | Multivariate analysis | |
|---|---|---|---|---|
| Age (Y) | 58 (9.6) | 50.3 (12.5) | <0.001 | OR 1.04 (1.02–1.06; p = 0.001) |
| Gender (M:F) | 113:28 (80.1:19.9) | 4692:6561 (41.7:58.3) | 0.002 | |
| BMI (kg/m2) | 29.1 (5.7) | 26.7 (4.7) | <0.001 | |
| Waist circumference (cm) | 100.5 (16.6) | 90.3 (13.5) | <0.001 | |
| Systolic/diastolic blood pressure (mmHg) | 137.0 (16.6)/80.5 (10) | 130.1 (16.8)/77.8 (9.8) | <0.001 | |
| Liver test | ||||
| ALT (IU/L) | 39.8 (37.9) | 24.2 (16.9) | <0.001 | OR 1.02 (1.01–1.03; p < 0.001) OR 1.005 (1.003–1.007; p < 0.001) |
| AST (IU/L) | 39.9 (30.9) | 24.2 (12.2) | <0.001 | |
| GGT (IU/L) | 102.0 (127.1) | 30.7 (48.8) | <0.001 | |
| Alkaline phosphatase (IU/L) | 87.3 (38.3) | 71.7 (28.5) | <0.001 | |
| Bilirubin (mg/dl) | 1.5 (0.6) | 1.4 (17.7) | 0.7 | |
| Abnormal transaminases (AST or ALT > 40 IU/L) | 54 (38.3) | 1059 (9.4) | <0.001 | |
| Healthy transaminase cutoffs (ALT <30 male or <19 female) | 103 (73) | 5863 (51.9) | <0.001 | |
| Albumin (g/dl) | 4.4 (0.4) | 4.5 (0.3) | 0.01 | |
| Glucose (mg/dl) | 103.8 (47.3) | 91.4 (28.8) | <0.001 | |
| Platelets (x103) | 219.7 (83.4) | 247 (61.6) | <0.001 | OR 0.993 (0.989–0.997; p < 0.001) |
| HDL cholesterol (mg/dl) | 57.4 (17.5) | 58.8 (16.1) | <0.001 | |
| Triglycerides (mg/dl) | 169.8 (113.2) | 140.8 (98.1) | <0.001 | |
| Metabolic syndrome (NCEP ATP III) | 36 (25.5) | 1729 (15.3) | <0.001 | OR 2.1 (1.4–3.3; p = 0.001) |
| HCV Ab+ | 2 (1.4) | 141 (1.2) | 0.9 | |
| HBsAg+ | 0 (0) | 90 (0.8) | 0.3 | |
| Harmful use of alcohol | 28 (19.9) | 1021 (9.0) | <0.001 | OR 1.8 (1.05–3.1; p = 0.03) |
Note: Highly suggestive cACLD (LSM > 15 kPa) vs. absence of cACLD. Quantitative data are expressed as mean (standard deviation). Qualitative data are expressed as number and percentage. Variables included in the multivariate analysis: age, gender, ALT, AST, GGT, alkaline phosphatase, platelets, metabolic syndrome, alcohol consumption.