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. 2021 Sep 2;297(4):101162. doi: 10.1016/j.jbc.2021.101162

Figure 2.

Figure 2

CDK7i-resistant cells upregulate the expression of extracellular transport genes.A and B, Pearson correlation analysis using RNA-Seq gene expression data from the sensitive/parental and resistant cells treated with vehicle or THZ1 (50–75 nM) for 48 h: MDA-MB-231 Vehicle (231 Veh), MDA-MB-231 THZ1 (231 THZ1), MDA-MB-231R Vehicle (231R Veh), MDA-MB-231R THZ1 (231R THZ1), MDA-MB-468 Vehicle (468 Veh), MDA-MB-468 THZ1 (468 THZ1), MDA-MB-468R Vehicle (468R Veh), and MDA-MB-468R THZ1 (468R THZ1). C, Venn diagrams indicating the number of differentially expressed transcripts when comparing the sensitive/parental expression profiles with those observed in the resistant MDA-MB-231R and MDA-MB-468R cells. D, list of significantly upregulated Gene Ontology pathways in resistant cells.