Skip to main content
. 2021 Sep 2;297(4):101162. doi: 10.1016/j.jbc.2021.101162

Figure 4.

Figure 4

ABCG2 inhibition restores CDK7i responsiveness in resistant TNBC cells.A, protein verification of siRNA-mediated silencing of ABCG2 in MDA-MB-468R and MDA-MB-231R cells after 72 h. B, seventy-two–hour THZ1 dose–response curve in MDA-MB-468R and MDA-MB-231R cells initiated 48 h after transfection. The siABCG2 curves are significantly different than the siNS curves according to a sum-of-squares F test with p-value <0.5. C, THZ1 dose–response curves for MDA-MB-468 and MDA-MB-231-sensitive/parental and resistant cells that were cotreated with either vehicle or GF120918 (1.5 μM) for 72 h. D, THZ1 dose–response curves for MDA-MB-468 and MDA-MB-231-sensitive/parental and resistant cells that were cotreated with vehicle or Ko143 (100 nM) for 72 h. The GF and Ko143 cotreatment curves are significantly different from their resistant curve counterparts treated with vehicle, according to a sum-of-squares F test with a p-value <0.05.