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. 2021 Sep 24;9:742858. doi: 10.3389/fbioe.2021.742858

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Copyright © 2021 Pichlsberger, Jerman, Obradović, Tratnjek, Macedo, Mendes, Fonte, Hoegler, Sundl, Fuchs, Schoeberlein, Kreft, Mojsilović and Lang-Olip.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The schematic presentation of the PnD characterization and (B) verification in vitro. The sEV derived from perinatal MSC are overall the most characterized and in vitro tested PnD used in skin wound healing in preclinical studies. Conversely, the least characterized and in vitro tested PnD are the perinatal tissues. The commercially available PnD or the PnD that have been described in the previous studies by the same authors, were defined as characterized in vitro, although the exact data were not provided in the actual study.