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. 2021 Sep 24;15:735387. doi: 10.3389/fnbeh.2021.735387

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Copyright © 2021 Grieco, Bernstein, Biemans, Bikovski, Burnett, Cushman, van Dam, Fry, Richmond-Hacham, Homberg, Kas, Kessels, Koopmans, Krashes, Krishnan, Logan, Loos, McCann, Parduzi, Pick, Prevot, Riedel, Robinson, Sadighi, Smit, Sonntag, Roelofs, Tegelenbosch and Noldus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Assessment of food and water consumption in the PhenoTyper. (A) Home-cage arena i ndicating the location of defined zones of interest including food and water zones adjacent to the food hopper and water bottle. Treatment with AM251 induced a decrease in body weight (B), food intake (C) and water intake (D). They also spent less time in the food zone compared with controls (E) and displayed lower levels of ambulatory activity (F). Repeated administration of AM251 suppressed food intake (G) with home cage observations indicating a reduced time in food zone each night following drug treatment (H). The figure is adapted from Riedel et al. (2009). *P < 0.05; **P < 0.01; ***P < 0.001.