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. 2021 Sep 24;15:735387. doi: 10.3389/fnbeh.2021.735387

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Copyright © 2021 Grieco, Bernstein, Biemans, Bikovski, Burnett, Cushman, van Dam, Fry, Richmond-Hacham, Homberg, Kas, Kessels, Koopmans, Krashes, Krishnan, Logan, Loos, McCann, Parduzi, Pick, Prevot, Riedel, Robinson, Sadighi, Smit, Sonntag, Roelofs, Tegelenbosch and Noldus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The CognitionWall for identifying discrimination learning impairments. The CognitionWall is an opaque Perspex wall with three entrances that is placed in front of a food dispenser inside PhenoTyper. (B) In the discrimination learning test, mice are rewarded with a food pellet (blue dot) when they choose to pass through one of the three entrances; in this example, the left-most entrance. In the reversal learning test (not shown), the rewarding entrance is switched to another one, for example the right-most entrance. The scheme is adapted from www.sylics.com. (C) Top view of the Combicage. Left, the PhenoTyper home-cage. Right, MedAssociates operant chamber. The test animal can move between the two parts through a custom connection tube. The figure is adapted from Remmelink et al. (2017).