Table 1.
m6A methylation related to tumorigenesis.
| m6A methylated related genes | Tissues/cells | Express trend | Regulation of genes | Function | Diseases |
|---|---|---|---|---|---|
| Writers: | |||||
| METTL3 | Human lung cancer cell | up | EGFR, TAZ | Facilitate translation of certain miRNAs (33) | Lung cancer |
| Human BCa tissue | up | AFF4, MYC, IKBKB and RELA; pri-miR221/222 | Proliferation, invasion, and survival (34, 35) | Bladder cancer | |
| AGS and MKN45 | up | AKT signaling pathway; GFI1 | Proliferation and mobility (36, 37) | Gastric cancer | |
| Human prostate cancer cell | up | GLI1 | Apoptosis (38) | Prostate cancer | |
| Human breast cancer cell | up | HBXIP, miRNA let-7g; Bcl-2 | Proliferation and apoptosis (39, 40) | Breast cancer | |
| AML cell | up | CEBPZ | Enhances its translation (41) | AML | |
| Bc cell | up | MALAT1, miR-26b | EMT, migration, and invasion (26) | BC | |
| cardiomyocytes | up | miR-143-3p, Yap and Ctnnd1 | Proliferation (42) | myocardial infarction | |
| METTL14 | SMMC-7721 and Hep3B cell | down | DGCR8, microRNA 126 | Tumor metastasis (43) | HCC |
| CRC tissues and Cell | down | miR-375, YAP1 | Migration and invasion (44) | Colon cancer | |
| Mouse hematopoietic stem/progenitor cell | up | SPI1, MYB and MYC | Unknow (45) | AML | |
| Endometrial tumor | up | AKT signaling; PHLPP2 | Proliferation and tumorigenicity (46) | Endometrial | |
| Nucleus pulposus | up | miR-26a-5p, NLRP3 | Viability (47) | Intervertebral disc degeneration | |
| WTAP | Human cholangiocarcinoma cell | up | MMP7, MMP28 and cathepsin H and Muc1 | Unknow (48) | Cholangiocarcinoma |
| RCC cell lines and tissues | up | CDK2 | Proliferation (49) | RCC | |
| HCC cell | up | ETS1 | Proliferation (50) | HCC | |
| Ovarian tissues, SKOV3 | up | MAPK and AKT signaling pathways | Proliferation, migration and Apoptosis (51) | HGSOC | |
| Human bladder transitional cell cancer tissues | up | Unknow | Unknow (52) | Bladder cancer | |
| Human Pancreatic ductal adenocarcinoma (PDAC) | up | CCHC-type zinc finger nucleic acid binding protein | Promote the translation (53) | (PDAC) | |
| RBM15 | 32DWT18 myeloid precursor cell line | up | HES1 | Hematopoiesis (54) | |
| Erasers: | |||||
| FTO | MLL-rearranged AML cell lines | up | ASB2 and RARA | cell differentiation (55) | AML |
| HCC tissues and HCC cell lines | up | PKM2 | Accelerate the translated production (56) | HCC | |
| NSCLC cell | up | USP7 | Colony formation (57) | Lung cancer | |
| MDA-MB-231 cell and MCF-7 cell | up | BNIP3 | Growth retardation、metastasis (58) | Breast cancer | |
| Human umbilical cord-derived mesenchymal stem cells | up | HUC-MSCs-derived exosomal miR-627-5p | Glucose and lipid metabolism (59) | Non-alcoholic fatty liver disease | |
| Melanoma cell | up | PD-1,CXCR4 and SOX10 | Increased RNA decay (60) | Melanoma | |
| ALKBH5 | Human breast cancer cell lines | up | NANOG | Tumor initiation (61) | Breast cancer |
| Human GSC cell lines | up | FOXM1 | Nascent transcripts (62) | Glioblastoa | |
| SGC-7901, BGC-823, and GES-1 cells | up | NEAT1 | Invasion and metastasis (63) | Gastric cancer | |
| Readers | |||||
| YTHDC1 | Oocyte | - | Unknow | Increases translation efficiency (64) | |
| YTHDC2 | Human colon adenocarcinoma cell lines | up | HIF-1α | Metastasis (65) | Colon cancer |
| YTHDF1 | HeLa cell | up | Unknow | mRNA translation (20) | |
| hepatocellular carcinoma cell | up | Unknow | Cell cycle progression metabolism (66) | HCC | |
| Colorectal tissues | up | Wnt/β-catenin pathway | Unknow (67) | CRC | |
| YTHDF2 | Hematopoietic stem cell | Tal1 mRNA | Decay (68) | ||
| YTHDF3 | Human colorectal cell line | up | lncRNA GAS5, YAP | Promote Inc RNA degradation (69) | Colorectal cancer |