Table 1.
Clinical and lung function characteristics according to nocturnal hypoxemia.
| <10% with SpO2 <90% | ≥10% with SpO2 <90% | p | |
|---|---|---|---|
| (n = 36) | (n = 7) | ||
| Age (years) | 28.9 ± 9 | 24.7 ± 10.4 | ns |
| Weight (kg) | 63.8 ± 8.7 | 61.7 ± 23.6 | ns |
| Height (cm) | 170.5 ± 8.9 | 169.6 ± 7.2 | ns |
| BMI (kg/m2) | 21.8 ± 2.9 | 21.5 ± 8.6 | ns |
| Heart rate (bpm) | 77.6 ± 12 | 84.6 ± 12.1 | ns |
| SBP (mmHg) | 118.7 ± 17.4 | 121.3 ± 9 | ns |
| DBP (mmHg) | 66.8 ± 10.6 | 64.9 ± 8.1 | ns |
| Diurnal SpO2 (%) | 97.7 ± 2.0 | 95.7 ± 2.0 | 0.026 |
| Waking PaO2 (mmHg) | 89.4 ± 18.1 | 74.6 ± 11 | 0.022 |
| Mean sleep SpO2 | 94.8 ± 2.1 | 87.6 ± 2.8 | <0.001 |
| Hemolytic like complications (%) | 14 | 57 | 0.026 |
| Vaso occlusive like complication (%) | 89 | 86 | ns |
| Hydroxyurea treatment (%) | 69 | 71 | ns |
| FVC (L) | 3.1 ± 0.8 | 2.9 ± 0.7 | ns |
| FEV1 (L) | 2.7 ± 0.6 | 2.4 ± 0.6 | ns |
| FEV1/FVC | 82.3 ± 7.7 | 83.9 ± 6.4 | ns |
| TLC (L) | 4.6 ± 1.3 | 4.1 ± 2 | ns |
| RV (L) | 1.5 ± 0.5 | 1.7 ± 0.5 | ns |
| RV/TLC | 32.2 ± 7.2 | 35.4 ± 5.3 | ns |
| DLCO [mL/(min x mmHg)] | 21.1 ± 6.3 | 18.1 ± 8.5 | ns |
| KCO (mL/(min x mmHg x L)) | 5.1 ± 1.3 | 4.7 ± 2.5 | ns |
| AV (L) | 4 ± 0.9 | 3.8 ± 0.9 | ns |
BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; PaO2,arterial partial pressure of oxygen; FVC, forced vital capacity; FEV1, forced expiratory volume in one second; RV, Residual Volume; TLC, Total Lung Capacity; DLCO, diffusing capacity for carbon monoxide; KCO, DLCO/AV; AV, Alveolar Volume; ns, non significant. Bold p values mean Statistically significant.