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. 2021 Oct 8;37(4):109881. doi: 10.1016/j.celrep.2021.109881

Figure 4.

Figure 4

SARS-CoV-2 can escape neutralization by 2B04 and 2H04

(A) Logo plot depicting escape mutants generated by selection pressure from 2B04 or 2H04 using a chimeric VSV expressing SARS-CoV-2 spike.

(B) Identity and frequency of mutations seen in clinical isolates of SARS-CoV-2 at identical positions as the VSV-SARS-CoV-2 escape mutants. The right axis shows the number of total sequences with mutations at each residue position, out of a total 106,606 sequences. Logo plots were generated using dmslogo (Bloom lab).

(C) RBD with ACE2 contacts colored in green, and 2H04 escape mutants colored in magenta.

(D) Ribbon diagram showing escape mutants at the binding interface of 2H04 on the RBD.

(E) RBD with ACE2 contacts colored in green, and 2B04 escape mutants colored in cyan.

(F) Ribbon diagram showing escape mutants at the binding interface of 2B04 on the RBD.